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Downstream Scientist in Toronto Ontario, Canada

Were hiring a Downstream Scientist for our client, a global pharmaceutical company, to join their team. This is a 1-year and 1-month contract concluding in April 2021.



About this role

Responsibilities

  • Responsible for specific scientific, technical and compliance aspects of assigned project, ensure that objectives are met. Plan and supervise execution of product development activities (develop, improve, scale-up processes, and provide material and documentation for purified proteins or viruses) within platform for the project to ensure scientific and technical excellence. Supervise, train, motivate and empower technical personnel to perform the experimental and processing tasks.
  • To ensure good scientific and technical leadership within BRD and the platform, keep abreast of the current developments in relevant scientific and technical disciplines and ensure current developments are implemented when appropriate.
  • Prepare internal and external presentations, patent filings, research manuscripts and review articles as required.
  • Manage and develop competencies of direct reports. Ensure compliance of direct reports with GxP and other quality and documentation requirements, such as preparation of SOPs and BPRs. Provide leadership for data input, standardized formats, database creation and management, and implementation of corporate standards. Ensure that direct reports are well-informed about current policies, new directions and training initiatives. Ensure teamwork and empowerment of all direct reports. Coach and motivate staff to perform efficiently and achieve objectives on time, on budget.
  • Share information and harmonize development within BRD, and other departments such as Research, Manufacturing Technology, Industrial Operations, Quality Operations, Regulatory Affairs, Clinical/Medical as necessary. Ensure good teamwork and provide high quality deliverables, such as Technical reports, development reports within agreed timeframes. Support regulatory submission by participating in preparation of regulatory submission documents (CTA, IND, CTD).
  • In depth knowledge of experimental work and data analysis. Working knowledge of computer skills, scientific writing and presentations, supervisory/management/people development, communication skills, innovative thinking, and a familiarity with strategic planning, balanced judgment, risk analysis and budget process is required.
  • Works with the policies, procedures and regulations as required by the Company and under Occupational Health and Safety Act. Supervises and monitors compliance with employment and health and safety legislation to ensure that employees work within the policies, procedures and regulations.
  • Development of purification processes for vaccine candidate supply. The process scale could arrange from 2L bioreactor scale to 200L bioreactor scale, and the purification process developed with targeted quality, yield and scalability requirement. The purification development needs to be transferable to clinical manufacturing platform for clinical trial material production. Expertise required includes various chromatography separation, buffer exchange and tangential flow filtration, centrifugation, sonication, protein stabilization during the purification process and chemical treatment as required.
  • Use of analytical methods for measuring purity, quality and process yield by assays such as protein content, SDS-PAGE, ELISA, HPLC, LAL et al. Development of appropriate in-process testing for the purification process development if needed.
  • Support for GMP manufacturing including process technology transfer, equipment selection and validation, process flows, vendor and raw materials selection, and process trouble shooting.


About you

Requirements

  • PhD
    (Biochemistry, Biochemical Engineering, Microbiology,
    Chemistry) with 2+ years experience, or MSc (Biochemistry, Biochemical
    Engineering, Microbiology, Chemistry) with 5+ years experience, in protein
    purification, or vaccine development or relevant field.
  • In-depth
    knowledge of protein purification, primary recovery processes, process
    analytical technology and quality by design.
  • Working
    knowledge of microbiology, biochemistry, chemical engineering principles,
  • In-depth
    knowledge of experimental design, execution and data analysis.
  • Knowledge
    and experiences in continuous chromatography and continuous bioprocessing are
    assets.
  • Strong
    computer, scientific writing and presentations skills.
  • Proven
    supervisory/management/people development experience is required.
  • Highly
    organized and excellent communication, interpersonal and team leadership
    skills.
  • Familiarity
    with strategic planning and budget process.



What we offer

Why work with Brunel? We are proud to offer exciting career opportunities from over 100 offices globally in 42 countries. Advancing your career takes time and effort let us match you to your ideal position.




About us

Brunel has a reputation for working with some of the best in the business. Thats what we continually strive for. Over 40 years, weve created a global network of interesting clients and talented individuals working together through a vast array of services.

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